L-Sorbitol is widely used as a sugar substitute in various food products, particularly in sugar-free and low-calorie items like candies, chewing gum, and baked goods. Its low calorie content and minimal impact on blood sugar levels make it suitable for diabetics and those controlling weight. Its ability to retain moisture makes it a valuable ingredient in maintaining the freshness and texture of these products, and it helps prevent caking.

In the pharmaceutical industry, it serves as an excipient in tablets, syrups, and toothpaste, providing sweetness and improving the stability of medications. It is also used in medical applications such as laxatives, where it absorbs water and stimulates intestinal function, and in dialysis solutions for peritoneal dialysis.

Additionally, L-Sorbitol is utilized in cosmetics and personal care products as a humectant, helping to keep skin and hair hydrated in items like lotions, creams, and shampoos.

In the chemical industry, it acts as a precursor in the production of vitamin C and is used as a raw material in the manufacture of resins for the plastics industry.