“Direct WS-23 evidence: WS-23 was included among selective TRPM8 ligands, supporting use as a synthetic cooling agent via TRPM8 activation; skin benefit scope is sensory cooling only.”
WS-23 Cooling Agent (Methyl Diisopropyl Propionamide)
Cosmetics
Code: 2225
Gives a cooling sensation on the skin.
WS-23 Cooling Agent gives a cooling sensation on the skin.
Usage: For any product Who want to feel cool When in contact with the skin
Mixing method: Mix in oil
Rate of use: 0.1-0.5% (use as desired performance)
Product characteristics: White powder
Solubility: Can dissolve in any type of oil or Glycol or Ethyl Alcohol (50 degree heat can be used to accelerate dissolution).
INCI Name : Methyl diisopropyl propionamide
Examples of products using WS-23 Cooling Agent
StriVectin Hyaluronic Dual-Response Serum
Urban Decay All Nighter Long Lasting Makeup Setting Spray
Murad Environmental Shield Intensive-C Radiance Peel
SHISEIDO Extra Smooth Sun Protection Lotion Spf 30
- Room (25-40C)
- 36 Months from manufacturing or testing date.
- 0.10% - 0.50%
- 0.50%
- Add into oil phase. Heat tolerant.
- Avoid heat above 80C
- 0.00 - 0.00
- Soluble in Oil, Soluble in glycols, Soluble in Ethanol
- -
| Test Name | Specification |
|---|---|
| Appearance: | Crystalline Powder |
| Color: | White to off-white |
| Acidity (KOH): | 1.0 mg/g Max |
| Melting point: | 60-63C |
| Purity(N,2,3-Trimethyl-2-isopropyl Butanamide): | 99% Min |
| Heavy Metals (as Pb): | 10 mg/kg Max |
| Arsenic (As): | 3 mg/kg Max |
“Ingredient-family evidence: cooling compounds modulate TRPM8, the main receptor for innocuous cold sensation, supporting topical cooling claims for WS-23 as a TRPM8-active coolant.”
“Skin physiology evidence: cutaneous TRPM8-positive receptors act as skin cooling sensors, supporting the mechanism behind topical cooling sensations from TRPM8 agonists such as WS-23.”
“Closest skin-cell evidence: epidermal TRPM8 participates in keratinocyte proliferation/differentiation balance under cold-dependent conditions; this is mechanistic TRPM8 biology, not direct WS-23 cosmetic efficacy evidence.”
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