Phenyl vinyl sulfone is widely used in organic synthesis, particularly as a Michael acceptor in conjugate addition reactions. Its electron-deficient double bond makes it highly reactive towards nucleophiles, enabling the formation of carbon-carbon and carbon-heteroatom bonds. This property is valuable in the synthesis of complex organic molecules, including pharmaceuticals and agrochemicals.

In polymer chemistry, it serves as a cross-linking agent or monomer, contributing to the development of materials with enhanced thermal and chemical stability. Its ability to form stable covalent bonds makes it useful in creating high-performance polymers and coatings.

Additionally, phenyl vinyl sulfone is employed in bioconjugation techniques, where it reacts with thiol groups in proteins or peptides to create stable thioether linkages. This application is crucial in drug delivery systems, protein labeling, and the development of antibody-drug conjugates.

Its versatility and reactivity make it a valuable tool in research and industrial applications across various fields, including textile processing as a modifier in dyeing and finishing.