Gimatecan
≥99%
Reagent
Code: #102633
CAS Number
292618-32-7
blur_circular Chemical Specifications
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Molecular Information
Weight
447.48 g/mol
Formula
C₂₅H₂₅N₃O₅
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Storage & Handling
Storage
2-8°C, sealed, dry
description Product Description
Gimatecan is primarily utilized in the field of oncology for its potent anticancer properties. It is a topoisomerase I inhibitor, which means it works by interfering with the enzyme topoisomerase I, essential for DNA replication and cell division. This interference leads to DNA damage in cancer cells, ultimately causing their death.
The chemical is particularly effective in treating various solid tumors, including ovarian, breast, and lung cancers. Its ability to cross the blood-brain barrier also makes it a promising candidate for treating brain tumors and metastases.
In clinical settings, Gimatecan is often administered orally, which enhances patient compliance compared to intravenous treatments. It has shown efficacy in both monotherapy and combination therapy, where it is used alongside other chemotherapeutic agents to enhance overall treatment outcomes.
Research continues to explore its potential in other types of cancers and its effectiveness in overcoming drug resistance, a common challenge in cancer treatment. Its targeted mechanism of action and oral bioavailability make it a valuable tool in the ongoing battle against cancer.
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Gimatecan
Gimatecan is primarily utilized in the field of oncology for its potent anticancer properties. It is a topoisomerase I inhibitor, which means it works by interfering with the enzyme topoisomerase I, essential for DNA replication and cell division. This interference leads to DNA damage in cancer cells, ultimately causing their death.
The chemical is particularly effective in treating various solid tumors, including ovarian, breast, and lung cancers. Its ability to cross the blood-brain barrier also makes it a promising candidate for treating brain tumors and metastases.
In clinical settings, Gimatecan is often administered orally, which enhances patient compliance compared to intravenous treatments. It has shown efficacy in both monotherapy and combination therapy, where it is used alongside other chemotherapeutic agents to enhance overall treatment outcomes.
Research continues to explore its potential in other types of cancers and its effectiveness in overcoming drug resistance, a common challenge in cancer treatment. Its targeted mechanism of action and oral bioavailability make it a valuable tool in the ongoing battle against cancer.
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