Aldehyde dehydrogenase is widely used in biochemical research and clinical diagnostics due to its role in alcohol metabolism and detoxification pathways. It is employed in assays to measure alcohol dehydrogenase activity and to study metabolic disorders related to aldehyde accumulation, such as alcohol flush reaction. The enzyme is also utilized in the development of biosensors for detecting acetaldehyde levels in blood or breath, aiding in the diagnosis of liver disease and alcohol intolerance. In pharmaceutical research, aldehyde dehydrogenase activity is monitored to evaluate drug metabolism and to design treatments for alcohol dependence. Additionally, it serves as a biomarker in stem cell research, particularly in identifying and isolating certain populations of stem and progenitor cells, especially in hematopoietic systems.