“Closest piperine evidence: 20 mg piperine markedly increased curcumin bioavailability in human volunteers.”
Black Pepper Extract (Water-Soluble)
Food
Code: 254214
Water-soluble black pepper fruit extract powder for food supplement formulations; used as a low-dose piperine-equivalent bioavailability enhancer in capsules, sachets and drink mixes.
Black Pepper Extract (Water-Soluble) is a brown, cocoa-like Piper nigrum fruit extract powder designed for food supplement formats that need easier dispersion in water than conventional black pepper oleoresin or native piperine powder. It is positioned as a low-dose bioavailability enhancer for nutraceutical powders, capsules, sachets and flavored drink systems. Exact piperine standardization should be confirmed from the working COA before final label calculation.
| Function | Typical use context | Evidence framing | Sources |
|---|---|---|---|
| Bioavailability enhancement | Commonly used at low piperine-equivalent levels with curcuminoids, polyphenols and selected nutrients. | Human pharmacokinetic work with curcumin showed a large exposure increase when 20 mg piperine was co-administered, but the effect depends strongly on the paired active and formulation. | Shoba et al., 1998 |
| Water-compatible delivery | Instant powders, stick packs, functional beverages, effervescent systems and capsule blends where uniform distribution matters. | Water-soluble or water-dispersible carrier systems improve handling and dose uniformity; they do not remove piperine's interaction potential. | Formulation-dependent |
| Metabolic / thermogenic support | Secondary positioning in weight-management and metabolism formulas. | Mechanistic and preclinical evidence exists, but human weight-loss outcomes are not established enough for disease or fat-loss claims. | Black pepper review |
Mechanism and formulation notes
- Mechanism: Piperine can modulate intestinal transport and metabolic pathways, including P-glycoprotein and CYP3A4, which is why it can increase exposure of co-administered actives.
- Water phase use: Pre-disperse in a small portion of water or syrup base before adding to the main batch. In clear beverages, run a haze and sediment check because carrier systems can differ by supplier lot.
- pH and heat: Suitable starting pH range is approximately 3.0-7.5. Avoid prolonged high heat; add after pasteurization or during cool-down where process design allows.
- Sensory: Expect a mild peppery note and brown color contribution. Flavor masking may be needed in low-flavor or clear products.
Usage and safety
- Suggested daily range for formulation: 2-10 mg/day piperine-equivalent, with 5 mg/day as a conservative development target until the supplier assay and market regulations are confirmed.
- Interaction warning: Piperine may increase exposure to prescription drugs or high-potency actives, especially CYP3A4 or P-glycoprotein substrates. Use extra caution with anticoagulants, antiplatelets, antihypertensives, anti-diabetic drugs, sedatives, immunosuppressants and narrow-therapeutic-index medicines.
- Not for high-risk users without medical advice: Avoid unsupervised use during pregnancy or breastfeeding, before surgery, in active gastrointestinal ulceration, or when taking regular medication.
- Regulatory note: Finished-product dose, warning text and claims must be checked against the target market's food supplement rules.
- Fine brown cocoa-like powder; characteristic black pepper odor
- Room (25-40C)
- 24 Months from manufacturing or testing date.
- 2mg - 10mg
- 5mg
- 2mg - 10mg
- 5mg
- Powder mixing for food/beverage (oil‑phase disperse or glycol premix)
- Heat Tolerant
- 0.00 - 0.00
- Soluble in Water, Dispersible in water
- Nutrient Supplement, Dietary Supplement
“Closest piperine evidence: piperine increased serum beta-carotene response during 14 days of supplementation.”
“Black pepper/piperine family evidence: reviewed potential use as an iron bioavailability enhancer in physically active healthy people.”
“Piperine-specific dietary evidence: 5 mg/day piperine for 12 weeks improved selected metabolic markers in NAFLD/early cirrhosis patients; not evidence for weight-loss claims.”
“Ingredient-family review: summarizes piperine bioavailability, bio-efficacy, delivery-system evidence and safety considerations for oral use.”
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