Lactitol Monohydrate Powder

Lactitol Monohydrate Powder
Food Code: 253026

Lactitol monohydrate ≥98% purity is a sugar alcohol derived from lactose that serves as a low-calorie sweetener and proven laxative for constipation relief.

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Lactitol monohydrate ≥98% purity is a sugar alcohol (polyol) derived from lactose through catalytic hydrogenation. This white crystalline powder serves as a low-calorie sweetener (2.0-2.4 kcal/g vs 4 kcal/g for sugar) with proven therapeutic benefits for digestive health.


Benefit Typical study dose* Key human findings High-quality sources
1 Bowel function improvement 10-40 g/day for 2-4 weeks Meta-analysis (n=663) showed increased weekly stool frequency and softened stools; EU authorized claim at 10 g/day PubMed/EFSA
2 Glycemic control 25 g single dose Minimal glucose/insulin rise (glycemic index ≈0 vs glucose=100); recognized for reducing post-prandial glycemic responses EFSA Journal
3 Dental health As sugar replacement Does not promote dental caries; helps maintain tooth mineralization when replacing sugars FDA/EFSA
4 Prebiotic effects 10-20 g/day for 2 weeks Increases Bifidobacterium levels and improves symptoms in constipated adults PubMed

*EU supplement claim requires 10 g lactitol once daily for bowel function benefit. Medical use (Pizensy®) typically 20 g daily.


Mechanistic highlights

  1. Osmotic action: Lactitol is poorly absorbed in the small intestine, creating an osmotic effect that draws water into the bowel lumen, softening stool and promoting regular bowel movements.
  2. Colonic fermentation: Gut bacteria ferment unabsorbed lactitol into short-chain fatty acids, lowering colonic pH and stimulating peristalsis while supporting beneficial microbiota.
  3. Minimal systemic absorption: Only 0.5-2% of oral lactitol is absorbed unchanged, resulting in negligible impact on blood glucose and insulin levels (ideal for diabetics).
  4. Non-cariogenic properties: Oral bacteria cannot effectively metabolize lactitol into cavity-causing acids, making it safe for dental health.


Safety & practical use

  • Usual supplemental range: 10-20 g once daily for constipation relief; adjust based on stool consistency
  • Upper-dose tolerance: Doses >20-30 g may cause gas, bloating, and diarrhea; products with >10% polyols require laxative effect warning in EU
  • Drug interactions: Separate from oral medications by ≥2 hours to avoid absorption interference
  • FODMAP consideration: Lactitol is a high-FODMAP polyol; may trigger IBS symptoms in sensitive individuals
  • Contraindications: Avoid in galactosemia, GI obstruction; safety in pregnancy not established
  • Sweetness profile: Approximately 35-40% as sweet as sucrose; heat-stable for cooking/baking
  • Storage: Store in cool, dry place; hygroscopic nature requires moisture-proof packaging

  • Room (25-40C)
  • 24 Months from manufacturing or testing date.
  • Add at last step. Avoid temperature above 40C.
  • Avoid heat above 40C
  • 3.50 - 5.50
  • Soluble in Water, Dispersible in water
  • -
Test Name Specification
Color White
Appearance Crystalline powder
Assay (on dry basis), w/% 95.0–102.0
Other polyols (on dry basis), w/% ≤2.5
Moisture, w/% ≤1.5
Reducing sugars, w/% ≤0.1
Chlorides (on dry basis), mg/kg ≤100.0
Sulfates (on dry basis), mg/kg ≤200.0
Residue on ignition (on dry basis), w/% ≤0.1
Nickel (Ni), mg/kg ≤2.0
Lead (Pb), mg/kg ≤1.0

Lactitol Monohydrate Powder

Lactitol monohydrate ≥98% purity is a sugar alcohol derived from lactose that serves as a low-calorie sweetener and proven laxative for constipation relief.

Lactitol monohydrate ≥98% purity is a sugar alcohol (polyol) derived from lactose through catalytic hydrogenation. This white crystalline powder serves as a low-calorie sweetener (2.0-2.4 kcal/g vs 4 kcal/g for sugar) with proven therapeutic benefits for digestive health.


Benefit Typical study dose* Key human findings High-quality sources
1 Bowel function improvement 10-40 g/day for 2-4 weeks Meta-analysis (n=663) showed increased weekly stool frequency and softened stools; EU authorized claim at 10 g/day PubMed/EFSA
2 Glycemic control 25 g single dose Minimal glucose/insulin rise (glycemic index ≈0 vs glucose=100); recognized for reducing post-prandial glycemic responses EFSA Journal
3 Dental health As sugar replacement Does not promote dental caries; helps maintain tooth mineralization when replacing sugars FDA/EFSA
4 Prebiotic effects 10-20 g/day for 2 weeks Increases Bifidobacterium levels and improves symptoms in constipated adults PubMed

*EU supplement claim requires 10 g lactitol once daily for bowel function benefit. Medical use (Pizensy®) typically 20 g daily.


Mechanistic highlights

  1. Osmotic action: Lactitol is poorly absorbed in the small intestine, creating an osmotic effect that draws water into the bowel lumen, softening stool and promoting regular bowel movements.
  2. Colonic fermentation: Gut bacteria ferment unabsorbed lactitol into short-chain fatty acids, lowering colonic pH and stimulating peristalsis while supporting beneficial microbiota.
  3. Minimal systemic absorption: Only 0.5-2% of oral lactitol is absorbed unchanged, resulting in negligible impact on blood glucose and insulin levels (ideal for diabetics).
  4. Non-cariogenic properties: Oral bacteria cannot effectively metabolize lactitol into cavity-causing acids, making it safe for dental health.


Safety & practical use

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