Benzyl-PEG8-Ots is widely used as a reagent in organic synthesis, particularly in the modification of biomolecules. Its primary application lies in the field of bioconjugation, where it serves as a linker to attach polyethylene glycol (PEG) chains to various substrates, such as proteins, peptides, or small molecules. This process, known as PEGylation, enhances the solubility, stability, and bioavailability of the conjugated molecules, making it valuable in drug delivery systems and therapeutic formulations. Additionally, it is utilized in the development of prodrugs and targeted therapies, where controlled release or site-specific delivery is required. Its benzyl group provides a protective function, which can be selectively removed under specific conditions, allowing for precise chemical modifications. This compound is also employed in material science for surface functionalization and in the creation of advanced polymeric materials.