Poly(ethylene glycol) bis(carboxymethyl) ether is widely used in various industrial and scientific applications due to its bifunctional nature and water solubility. It is commonly employed as a crosslinking agent in the synthesis of hydrogels, which are utilized in drug delivery systems, wound healing, and tissue engineering. Its ability to form stable networks makes it valuable in creating biocompatible materials for medical applications.

In the field of biotechnology, it serves as a spacer or linker in the conjugation of proteins, peptides, and other biomolecules, enhancing their stability and functionality. This is particularly useful in diagnostic assays and therapeutic formulations. Additionally, it is used in surface modification to improve the hydrophilicity and biocompatibility of materials, making it suitable for coatings in medical devices and implants.

Its role in chemical synthesis includes acting as a solubilizing agent for hydrophobic compounds, facilitating reactions in aqueous environments. It is also utilized in the preparation of nanoparticles and micelles for targeted drug delivery systems. Furthermore, it finds applications in the development of adhesives, coatings, and lubricants due to its ability to modify rheological properties and enhance performance.