Gamma-secretase modulators are primarily used in the field of medical research and therapeutics, particularly in the study and treatment of Alzheimer's disease. These compounds influence the activity of the gamma-secretase enzyme, which is involved in the processing of amyloid precursor protein (APP). By modulating this enzyme, they can potentially reduce the production of toxic amyloid-beta peptides, which are associated with the formation of amyloid plaques in the brain, a hallmark of Alzheimer's disease. This makes gamma-secretase modulators a promising target for developing drugs aimed at slowing or halting the progression of the disease. Additionally, research is ongoing to explore their potential applications in other conditions where gamma-secretase plays a role, such as certain types of cancer and developmental disorders.