XL888 is primarily utilized in the field of medical research, particularly in the study of cancer therapies. It functions as a potent inhibitor of heat shock protein 90 (HSP90), which plays a crucial role in the stabilization and function of various proteins involved in cancer cell growth and survival. By targeting HSP90, XL888 disrupts the signaling pathways that cancer cells rely on, thereby inhibiting their proliferation and promoting apoptosis. This makes it a valuable tool in preclinical studies aimed at understanding the mechanisms of cancer and developing new therapeutic strategies. Additionally, XL888 is being investigated for its potential to enhance the efficacy of other anticancer agents when used in combination therapies. Its application extends to exploring resistance mechanisms in cancer treatment, providing insights into overcoming drug resistance and improving patient outcomes.