1-Boc-5-iodoindole is widely used in organic synthesis as a key intermediate for constructing complex indole derivatives. Its Boc (tert-butoxycarbonyl) protecting group allows for selective functionalization at other positions of the indole ring, while the iodine atom serves as a reactive site for cross-coupling reactions, such as Suzuki or Sonogashira couplings. This compound is particularly valuable in pharmaceutical research for developing biologically active molecules, including potential drug candidates targeting neurological disorders or cancer. Additionally, it is employed in the synthesis of natural products and advanced materials, where indole scaffolds play a critical role.