6-amino-8-chloro-4-((3-chloro-4-fluorophenyl)amino)quinoline-3-carbonitrile
95%
Reagent
Code: #137523
CAS Number
915364-18-0
blur_circular Chemical Specifications
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Molecular Information
Weight
347.17 g/mol
Formula
C₁₆H₉Cl₂FN₄
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Registry Numbers
MDL Number
MFCD13181204
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Storage & Handling
Storage
2-8°C, dry, closed
description Product Description
Used as a key intermediate in the synthesis of tyrosine kinase inhibitors, particularly in the development of anticancer agents. It plays a role in targeting signaling pathways involved in tumor growth and progression, especially in compounds designed to inhibit epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK). Its structure supports high binding affinity to mutant forms of these kinases, making it valuable in creating targeted therapies for non-small cell lung cancer and other malignancies. Also utilized in research settings to develop new pharmaceuticals with improved selectivity and reduced resistance profiles.
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