Used as a buffering agent in analytical chemistry, particularly in electrophoresis and chromatography, where it helps maintain stable pH conditions. It also serves as a precursor in organic synthesis, especially in the preparation of malonic acid derivatives used in pharmaceuticals and agrochemicals. In some cases, it is employed in electroplating baths to improve metal deposition uniformity. Additionally, potassium malonate finds use in biochemical research for enzyme inhibition studies, as malonate compounds can act as competitive inhibitors of succinate dehydrogenase.