Orexin B (rat, mouse) is primarily used in neuroscience research to study the role of orexin peptides in regulating sleep-wake cycles, appetite, and energy homeostasis. It is often applied in animal models to investigate its effects on arousal, feeding behavior, and neuroendocrine functions. Researchers use it to explore its interaction with orexin receptors (OX1R and OX2R) and its potential implications in sleep disorders like narcolepsy and insomnia. Additionally, it is utilized in studies examining its influence on stress responses, addiction, and metabolic processes. The peptide is also a valuable tool in understanding the pathophysiology of conditions linked to orexin system dysregulation.