“Direct Acetyl Tetrapeptide-5 ingredient-family evidence: topical-peptide review lists acetyl tetrapeptide-5 and dipeptide-2 for dermatochalasis/eye-bag concerns by decreasing vascular permeability and glycation.”
Acetyl Tetrapeptide-5 (Powder)
Cosmetics
Code: 8806
Acetyl Tetrapeptide-5 powder for eye serums, under-eye gels, puffiness, eye-bag, and dark-circle appearance formulas. Freeze-dried powder form.
Acetyl Tetrapeptide-5 (Powder) is a cosmetic peptide powder for eye-area formulas targeting under-eye puffiness, eye-bag appearance, and dark-circle look.
Physical form: This product is supplied as a freeze-dried powder.
This peptide is widely used in eye-care concepts connected with glycation control and vascular-permeability support, two directions that are relevant when formulating for tired-looking, puffy, or dull under-eye skin. The powder format gives formulators more control over the solvent system, humectants, preservative system, and delivered peptide level.
Product Description: Use Acetyl Tetrapeptide-5 powder when developing eye serums, under-eye gels, eye creams, and lightweight leave-on products that need a clear peptide story for a fresher, smoother-looking eye area. It is especially useful when the formula needs to avoid the limitations of a ready-made peptide solution and instead build a custom base.
| Eye-area concern | Formula positioning |
|---|---|
| Puffiness | Helps support formulas designed for a less swollen-looking under-eye area. |
| Eye bags | Suitable for products targeting the appearance of under-eye bags and tired-looking eyes. |
| Dark-circle look | Fits brightening eye formulas where puffiness, dullness, and under-eye tone are addressed together. |
Usage: Eye serums, eye gels, under-eye creams, eye masks, lightweight leave-on products, and multi-peptide eye treatments.
Mixing method:
- Pre-dissolve in a small compatible water/glycol phase before adding to the main batch.
- Add during cool-down, preferably below 40°C, and avoid prolonged heat exposure.
- For eye-area products, keep the base mild and low-irritation; preservative and microbial-control design must be tested carefully.
- Check final pH, clarity, odor, color, and active stability before scale-up.
Usage rate: 0.1-1.0%, with 0.5% as a typical starting point. If preparing a stock solution, calculate dosage by delivered Acetyl Tetrapeptide-5 level and validate eye-area tolerance in the finished formula.
Product characteristics: white to off-white peptide powder.
Solubility: Pre-dissolve in water/glycol phase; avoid high-electrolyte or harsh preservative systems until compatibility is confirmed.
Storage: Keep tightly closed, dry, protected from light and heat. Refrigerated storage is preferred for long-term peptide stability.
- White to off-white powder
- Room (25-40C)
- 24 Months from manufacturing or testing date.
- 0.10% - 1.00%
- 0.50%
- Add into oil phase. Heat tolerant.
- Heat Tolerant
- 0.00 - 0.00
- Soluble in Water
“Ingredient-family evidence: bioactive-peptide review discusses acetyl tetrapeptide-5 as a cosmetic peptide used for puffy-eye concepts, while noting much evidence is supplier-reported rather than independently replicated.”
“Closest mechanism evidence: advanced glycation end products can increase endothelial permeability, supporting the rationale for anti-glycation approaches in puffiness/vascular-leakage concepts but not testing Acetyl Tetrapeptide-5 directly.”
“Closest mechanism evidence: AGE interaction with vessel-wall components is linked to increased vascular permeability and inflammation; relevant to the product's anti-glycation/vascular-permeability rationale, not direct cosmetic clinical proof.”
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