3-(5-bromo-4-methoxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione

98%

Reagent Code: #140684
fingerprint
CAS Number 2474671-29-7

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 353.17 g/mol
Formula C₁₄H₁₃BrN₂O₄
inventory_2 Storage & Handling
Storage 2-8°C, dry, light-proof

description Product Description

Used primarily in pharmaceutical research as a key intermediate in the synthesis of targeted protein degraders, particularly cereblon E3 ligase modulators. Its structure enables selective binding to cereblon, facilitating the degradation of disease-causing proteins. This makes it valuable in developing treatments for cancers such as multiple myeloma and other hematological malignancies. It is also explored in the design of PROTACs (proteolysis-targeting chimeras), where it serves as the E3 ligase recruiting moiety to induce degradation of specific target proteins. Due to its bromo and methoxy functional groups, it allows for further chemical modifications, enhancing its utility in structure-activity relationship studies and drug optimization.

shopping_cart Available Sizes & Pricing

Size Availability Unit Price Quantity
inventory 1mg
10-20 days ฿9,400.00
inventory 5mg
10-20 days ฿28,300.00
inventory 10mg
10-20 days ฿50,940.00
inventory 25mg
10-20 days ฿117,200.00
inventory bulk
10-20 days ฿0.00

Cart

No products

Subtotal: 0.00
Total 0.00 THB