Fmoc-N-methyl-L-valine
98%
Reagent
Code: #105128
Alias
Fmoc-N-methyl-L-valine ; N-fluorenylmethoxycarbonyl-N-methyl-L-valine
CAS Number
84000-11-3
blur_circular Chemical Specifications
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Molecular Information
Weight
353.41 g/mol
Formula
C₂₁H₂₃NO₄
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Registry Numbers
MDL Number
MFCD00153395
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Physical Properties
Melting Point
187-190 °C
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Storage & Handling
Storage
2~8°C
description Product Description
Fmoc-N-methyl-L-valine is widely used in peptide synthesis, particularly in solid-phase peptide synthesis (SPPS) methods. It serves as a protected amino acid derivative, where the Fmoc (fluorenylmethyloxycarbonyl) group acts as a temporary protecting group for the amine functionality. This allows for the sequential addition of amino acids to build peptides with high precision. The N-methyl group in the structure introduces steric hindrance, which can be beneficial in designing peptides with specific conformational properties or enhanced metabolic stability. This compound is especially valuable in the synthesis of complex peptides, including those used in pharmaceutical research, where controlled assembly and modification of peptide chains are critical. Its application extends to the development of peptide-based drugs, biomaterials, and probes for biochemical studies.
format_list_bulleted Product Specification
Test Parameter | Specification |
---|---|
Appearance | White To Off-White Powder |
Purity (HPLC) | 98-100% |
Melting Point | 180-190 |
Infrared Spectrum | Conforms To Structure |
Specific Rotation [α]20/D (C=1, DMF) | -65 to -71 °C |
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Fmoc-N-methyl-L-valine
Fmoc-N-methyl-L-valine is widely used in peptide synthesis, particularly in solid-phase peptide synthesis (SPPS) methods. It serves as a protected amino acid derivative, where the Fmoc (fluorenylmethyloxycarbonyl) group acts as a temporary protecting group for the amine functionality. This allows for the sequential addition of amino acids to build peptides with high precision. The N-methyl group in the structure introduces steric hindrance, which can be beneficial in designing peptides with specific conformational properties or enhanced metabolic stability. This compound is especially valuable in the synthesis of complex peptides, including those used in pharmaceutical research, where controlled assembly and modification of peptide chains are critical. Its application extends to the development of peptide-based drugs, biomaterials, and probes for biochemical studies.
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