Z-His-OH is widely used in peptide synthesis, particularly as a building block for creating complex peptides and proteins. Its role is crucial in the formation of histidine-containing sequences, which are essential for various biological functions. This compound is often employed in the pharmaceutical industry to develop peptide-based drugs, including those targeting metabolic disorders and immune system modulation. Additionally, it finds applications in biochemical research, where it is used to study enzyme mechanisms and protein interactions due to the unique properties of histidine in catalysis and metal binding. Its stability and compatibility with solid-phase peptide synthesis make it a valuable reagent in both academic and industrial laboratories.