Fmoc-1,2-trans-achc-oh is widely used in peptide synthesis as a protecting group for amino acids. The Fmoc group is particularly valued for its stability under basic conditions and its ease of removal under mild conditions, making it ideal for solid-phase peptide synthesis (SPPS). This compound is often employed to introduce specific conformational constraints into peptides, enhancing their stability and biological activity. It is also utilized in the development of peptidomimetics, which are compounds that mimic the structure and function of peptides but with improved pharmacokinetic properties. Additionally, Fmoc-1,2-trans-achc-oh is used in the synthesis of cyclic peptides, which are of interest in drug discovery due to their enhanced binding affinity and selectivity. Its application extends to the preparation of peptide-based materials and bioconjugates, which are used in various biomedical and biotechnological applications.