Trimethylsilylmethanol is primarily used as a protecting group in organic synthesis, particularly for alcohols and phenols. Its ability to form stable silyl ethers makes it valuable in multi-step reactions, where temporary protection of hydroxyl groups is necessary to prevent unwanted reactions. It is also employed in the preparation of silicon-containing polymers and resins, contributing to their stability and performance. Additionally, it serves as a reagent in the modification of surfaces, enhancing hydrophobicity or enabling further functionalization. In some cases, it is utilized in the synthesis of pharmaceutical intermediates, where its unique reactivity aids in achieving specific molecular structures.