GBR 12935 is primarily used in research settings to study the dopamine transporter (DAT) due to its high selectivity and potency as a dopamine reuptake inhibitor. It is a valuable tool in neuroscience for understanding the role of dopamine in various brain functions, including reward, motivation, and movement. Researchers use it to investigate the mechanisms of addiction, Parkinson's disease, and other dopamine-related disorders. Additionally, GBR 12935 has been employed in preclinical studies to explore the effects of dopamine modulation on behavior and cognition. Its ability to block dopamine reuptake makes it useful for creating animal models of conditions like substance abuse and psychiatric disorders.