Nalpha-Fmoc-Nomega-(2,2,4,6,7-pentamethyl-2,3-dihydrobenzo[b]furan-5-ylsulfonyl)-L-beta-homoarginine
>95%
Reagent
Code: #187796
Alias
Fmoc-β-HoArg(Pbf)-OH;N-fluorene methoxycarbonyl-N'-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-Horacinine
CAS Number
401915-53-5
Properties
Slightly soluble in water
science Other reagents with same CAS 401915-53-5
blur_circular Chemical Specifications
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Molecular Information
Weight
662.8 g/mol
Formula
C₃₅H₄₂N₄O₇S
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Registry Numbers
MDL Number
MFCD03788172
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Storage & Handling
Density
1.35±0.1 g/cm3
Storage
-20°C, sealed, dry
description Product Description
Used in solid-phase peptide synthesis as a protected amino acid building block. The Fmoc group allows for mild base deprotection, compatible with standard Fmoc strategies, while the omega-sulfonyl group protects the guanidine moiety of homoarginine, preventing side reactions during coupling. The 2,2,4,6,7-pentamethyl-2,3-dihydrobenzo[b]furan-5-ylsulfonyl (Pbf-like) protecting group is stable during synthesis but can be removed during final acidic cleavage, making it suitable for use in complex peptide assembly. This compound is particularly useful in the preparation of bioactive peptides where precise modification and protection of the arginine side chain are critical.
