Used in peptide synthesis, particularly for preparing neuroactive peptides and biomaterials where oxidative stability is crucial. The acetonide-protected catechol group allows selective deprotection under mild acidic conditions, enabling sequential conjugation strategies in solid-phase synthesis. Commonly applied in the development of radiolabeled peptides and enzyme-resistant peptide therapeutics due to enhanced side-chain protection during assembly. Also utilized in bioconjugation for imaging probes and targeted drug delivery systems where tyrosine mimicry with controlled reactivity is required.