trans-Nervonic acid is used in skincare formulations for its moisturizing and barrier-repair properties, supporting skin hydration and elasticity. It is commonly found in anti-aging creams and lotions. It plays a key role in promoting nerve cell function and myelin sheath maintenance, making it relevant in nutraceuticals targeting cognitive and neurological health. It is investigated for potential use in dietary supplements aimed at supporting brain development and function, especially in infants and aging populations. In research settings, it is utilized to study demyelinating diseases such as multiple sclerosis and Alzheimer's, as well as neural degeneration in children with brain lipid synthesis disorders. Additionally, it serves as a reference standard in biochemical analysis for separating and identifying trans-unsaturated fatty acids in biological samples.