Neohesperidose is a disaccharide primarily utilized as a key intermediate in the synthesis of bioactive flavonoid glycosides within the pharmaceutical and nutraceutical industries. These glycosides exhibit antioxidant, anti-inflammatory, and vascular protective properties. Naturally occurring in certain citrus plant extracts, neohesperidose supports the development of natural health products targeted at enhancing circulation and mitigating oxidative stress. While neohesperidose itself is not directly used for taste modulation, its derivatives, such as neohesperidin, are employed to mask bitterness in oral medications and functional foods, improving palatability without added sugars or artificial sweeteners. Furthermore, it aids in improving the stability and solubility of active compounds in drug formulation and delivery systems.