Rhapontigenin 3'-O-glucoside is utilized in biochemical and pharmaceutical research for its antioxidant and anti-inflammatory properties, aiding in the development of treatments for chronic conditions such as diabetes and cardiovascular diseases. Research indicates potential effects on cell growth regulation, making it valuable for cancer studies. It is commonly employed in laboratories for the isolation and analysis of natural compounds, particularly from rhubarb (Rheum species) and other bioactive herbs. In cosmetic applications, it features in skincare formulations to protect against oxidative stress and environmental damage, with promise in anti-aging products, hair growth promoters by extending the anagen phase, and topical anti-inflammatory treatments. Its plant-derived origin suits clean beauty and natural cosmetic lines.