SMIFH2 is widely used in organic synthesis as a selective reducing agent, particularly in the transformation of functional groups such as nitriles, amides, and esters into their corresponding amines or alcohols. It exhibits high chemoselectivity, making it valuable in complex molecule synthesis where preservation of other sensitive groups is required. It is especially effective in reductive amination reactions, offering high yields under mild conditions. Due to its stability and ease of handling, SMIFH2 is employed in pharmaceutical research and development for constructing nitrogen-containing bioactive molecules. Its application extends to late-stage functionalization in drug discovery, where controlled and efficient reduction steps are critical.