Alpha-Ketoglutaric acid (a-KG) is an essential component in the synthesis of various amino acids in the body.

In laboratory research, 1% concentration of alpha-Ketoglutaric acid at 12 weeks had the following effects:

1. a-Ketoglutarate (a-KG) Stimulated Procollagen Production in Cultured Human Dermal Fibroblasts (a-KG Stimulates Procollagen Synthesis in Fibroblast)

2. a-Ketoglutarate (a-KG) Enhanced Prolidase Activity in Cultured Human Dermal Fibroblasts ( a-KG can help enhance the function of Prolidase, which is an important part of collagen synthesis).

3. Decreased UVB-Induced Wrinkle Formation Following Long-Term Topical Application of a-KG on the Dorsal Skin of Hairless Mice (Long-term use of a-KG at 12 weeks can help reduce wrinkles. caused by UVB stimulation)

Compared with the use of a-KG with Retinoic Acid when UV light is applied to the skin to stimulate the appearance of wrinkles, it was found that a-KG can help reduce the appearance of wrinkles.

(Please study additional research results in the attachment)

Use: Use in any skin care regimen to reduce wrinkles.

Product characteristics: white powder

melting : soluble in water (not more than 5% at room temperature)

Usage rate: 1-2%

Storage: For long term storage Store at room temperature Avoid heat, humidity and sunlight. Shelf life is at least 24 months.

INCI Name : Ketoglutaric acid

Examples of products used alpha-ketoglutaric acid

IOPE Bio Essence Intensive Conditioning

IOPE men bio intensive

IOPE Intensive Conditioning Bio Redox a