Myristoyl pentapeptide-4 (1000ppm Solution)
- Product Code: 186668
an effective synthetic Myristoyl Pentapeptide with the sequence Myr-Lys-Leu-Ala-Lys-LysNH2 and good bioavailability, that was shown to significantly increase the skin‘s own keratin level, leading to promote eyelash growth. It can directly activate the keratin gene, as well as making eyelashes grow and become thick. It can significantly activate the keratin gene, promote its expression, and increase the growth of eyelashes and hair growth.
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Myristoyl pentapeptide-4 is an effective synthetic Myristoyl Pentapeptide with the sequence Myr-Lys-Leu-Ala-Lys-LysNH2 and good bioavailability, that was shown to significantly increase the skin‘s own keratin level, leading to promote eyelash growth. It can directly activate the keratin gene, as well as making eyelashes grow and become thick. It can significantly activate the keratin gene, promote its expression, and increase the growth of eyelashes and hair growth.
Research about Myristoyl pentapeptide-4 on hair growth:
| Evidence tier | Model & formulation | Key results | Mechanistic clues | Source |
|---|---|---|---|---|
| In vitro | Nanoliposomes co-loading Myr-KTTKS + Cu-GHK + acetyl-tetrapeptide-3 (CAM-NLPs) on human dermal-papilla cells & HaCaT keratinocytes | ↑ HDPC proliferation (+34 %), ↑ migration, ↑ VEGF & bFGF secretion, ↑ β-catenin, ↓ TGF-β1 | Collective matrix-building + angiogenic signal primes follicles for anagen | (researchgate.net) |
| Ex vivo | Isolated hairless-mouse skin | KTTKS & pal-KTTKS penetrate via follicular route; lipid tail improves retention around bulge region | Confirms that matrikine peptides can reach follicular targets through topical route | (biomolther.org) |
| Animal (C57BL/6) | 21-day topical Myr-KTTKS solution (0.5 mL day⁻¹) | Earlier anagen entry, ↑ total follicle count vs vehicle | ECM remodelling around follicles suggested driver | (medchemexpress.com) |
| CAM-NLPs spray (peptides 1 mg mL⁻¹) | Hair covered ≈ 90 % of depilated area by Day 12 (55 % faster than 2 % minoxidil); histology: thicker dermal sheath, richer capillary net | β-catenin/VEGF axis up-regulation | (researchgate.net) | |
| Human – eyelashes / brows | Polygrowth-factor serum (contains Myr-KTTKS + 6 other peptides & GFs), n = 30 women, 1 × nightly 90 d | +10.5 % length, +35 % thickness, +50.8 % curl; no adverse events | Multi-peptide synergy appears to translate from cell data | (pmc.ncbi.nlm.nih.gov) |
| Single-group trial of Myr-KTTKS + panthenol serum (NCT 06125730) – ongoing | Primary endpoints: length & density at 8 weeks | Results pending | (clinicaltrials.gov) | |
| Market/usage data | Leave-on scalp tonics / conditioners | CIR safety report notes max 0.0035 % in rinse-off & ≤0.012 % in leave-on; no irritation in HRIPT | Regulatory acceptance of very low use levels | (cir-safety.org) |
How might Myr-KTTKS help hair grow?
-
Matrikine signalling – the KTTKS core sequence mimics a collagen-I fragment, triggering fibroblasts around the follicle bulge to make new collagen I/III and fibronectin; this reinforces the dermal sheath and anchors growing fibres.
-
β-catenin activation – CAM-NLPs study shows significant up-regulation of follicular Wnt/β-catenin, the master switch for anagen entry.
-
Pro-angiogenic environment – VEGF ↑ improves dermal-papilla oxygen and nutrient supply.
-
Anti-catagen signals – down-regulation of TGF-β1 and other catagen inducers slows regression.
Usage: For products that accelerate eyelash or hair growth.
Mixing method: Mix in water (water-phase), avoid heat.
Usage rate: 5-10%
Product characteristics: Clear liquid with pH range 3-7.
Solubility: Soluble in water.
Storage: If you want to store it long term, keep it in a cool place at 6-8 degrees Celsius, avoid sunlight, heat, seal the lid tightly, have a shelf life of at least 2 years.
INCI Name : Water, Pentylene Glycol, 1,2-Hexanediol, Myristoyl pentapeptide-4
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Myristoyl pentapeptide-4 (1000ppm Solution)
an effective synthetic Myristoyl Pentapeptide with the sequence Myr-Lys-Leu-Ala-Lys-LysNH2 and good bioavailability, that was shown to significantly increase the skin‘s own keratin level, leading to promote eyelash growth. It can directly activate the keratin gene, as well as making eyelashes grow and become thick. It can significantly activate the keratin gene, promote its expression, and increase the growth of eyelashes and hair growth.
Myristoyl pentapeptide-4 is an effective synthetic Myristoyl Pentapeptide with the sequence Myr-Lys-Leu-Ala-Lys-LysNH2 and good bioavailability, that was shown to significantly increase the skin‘s own keratin level, leading to promote eyelash growth. It can directly activate the keratin gene, as well as making eyelashes grow and become thick. It can significantly activate the keratin gene, promote its expression, and increase the growth of eyelashes and hair growth.
Research about Myristoyl pentapeptide-4 on hair growth:
| Evidence tier | Model & formulation | Key results | Mechanistic clues | Source |
|---|---|---|---|---|
| In vitro | Nanoliposomes co-loading Myr-KTTKS + Cu-GHK + acetyl-tetrapeptide-3 (CAM-NLPs) on human dermal-papilla cells & HaCaT keratinocytes | ↑ HDPC proliferation (+34 %), ↑ migration, ↑ VEGF & bFGF secretion, ↑ β-catenin, ↓ TGF-β1 | Collective matrix-building + angiogenic signal primes follicles for anagen | (researchgate.net) |
| Ex vivo | Isolated hairless-mouse skin | KTTKS & pal-KTTKS penetrate via follicular route; lipid tail improves retention around bulge region | Confirms that matrikine peptides can reach follicular targets through topical route | (biomolther.org) |
| Animal (C57BL/6) | 21-day topical Myr-KTTKS solution (0.5 mL day⁻¹) | Earlier anagen entry, ↑ total follicle count vs vehicle | ECM remodelling around follicles suggested driver | (medchemexpress.com) |
| CAM-NLPs spray (peptides 1 mg mL⁻¹) | Hair covered ≈ 90 % of depilated area by Day 12 (55 % faster than 2 % minoxidil); histology: thicker dermal sheath, richer capillary net | β-catenin/VEGF axis up-regulation | (researchgate.net) | |
| Human – eyelashes / brows | Polygrowth-factor serum (contains Myr-KTTKS + 6 other peptides & GFs), n = 30 women, 1 × nightly 90 d | +10.5 % length, +35 % thickness, +50.8 % curl; no adverse events | Multi-peptide synergy appears to translate from cell data | (pmc.ncbi.nlm.nih.gov) |
| Single-group trial of Myr-KTTKS + panthenol serum (NCT 06125730) – ongoing | Primary endpoints: length & density at 8 weeks | Results pending | (clinicaltrials.gov) | |
| Market/usage data | Leave-on scalp tonics / conditioners | CIR safety report notes max 0.0035 % in rinse-off & ≤0.012 % in leave-on; no irritation in HRIPT | Regulatory acceptance of very low use levels | (cir-safety.org) |
How might Myr-KTTKS help hair grow?
-
Matrikine signalling – the KTTKS core sequence mimics a collagen-I fragment, triggering fibroblasts around the follicle bulge to make new collagen I/III and fibronectin; this reinforces the dermal sheath and anchors growing fibres.
-
β-catenin activation – CAM-NLPs study shows significant up-regulation of follicular Wnt/β-catenin, the master switch for anagen entry.
-
Pro-angiogenic environment – VEGF ↑ improves dermal-papilla oxygen and nutrient supply.
-
Anti-catagen signals – down-regulation of TGF-β1 and other catagen inducers slows regression.
Usage: For products that accelerate eyelash or hair growth.
Mixing method: Mix in water (water-phase), avoid heat.
Usage rate: 5-10%
Product characteristics: Clear liquid with pH range 3-7.
Solubility: Soluble in water.
Storage: If you want to store it long term, keep it in a cool place at 6-8 degrees Celsius, avoid sunlight, heat, seal the lid tightly, have a shelf life of at least 2 years.
INCI Name : Water, Pentylene Glycol, 1,2-Hexanediol, Myristoyl pentapeptide-4
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