excellent barrier repair, moisturizing, water-locking, anti-allergy, and soothing efficacy. However, due to its water and oil insolubility, ceramide tends to crystallize and precipitate during shelf life, limiting its application in cosmetics. Ceracare™ Oil is a clear oil that contains high concentration of 3 types of ceramides plus Phytosphingosine

Ceracare™ Oil (Clear Oil Ceramide, 2% Minimum Ceramide)

Ceramide has excellent barrier repair, moisturizing, water-locking, anti-allergy, and soothing efficacy. However, due to its water and oil insolubility, ceramide tends to crystallize and precipitate during shelf life, limiting its application in cosmetics. Ceracare™ Oil is a clear oil that contains high concentration of 3 types of ceramides plus Phytosphingosine.

Suitable for any oil based formulation.

Composition:

1. Ceramide NP (CERAMIDE NP)

2. Ceramide AP (CERAMIDE AP)

3. Ceramide EOP (CERAMIDE EOP)

4. Phytosphingosine (PHYTOSPHINGOSINE)

5. Octyldodecanol (OCTYLDODECANOL)

6. Pentylene Glycol (PENTYLENE GLYCOL)

Features and Advantages:

• Multiple ceramides

• Versatile applications

• Engineer/formulator friendly

• High content (2%)

• Mimics ceramides complex ratio in human skin

• Mixes well with GTCC, vegetable oils, etc., without heating

Applications:

• Transparent skincare oils

• Haircare products

• Color cosmetics

• Lotions

• Creams

Composition Effects:

• Ceramide NP: Rich fatty acids (C18:1/C18:2/C18/C16) to prevent water loss

• Ceramide AP: Promotes exfoliation and metabolism of stratum corneum

• Ceramide EOP: Links lipid bilayers

• Phytosphingosine: Important precursor for ceramides

Application Guidelines:

• Compatible with MCT Oil, wheat germ oil, jojoba seed oil, transparent appearance with no precipitation up to 1.5 months

• Precipitation risk with squalane, silicone oils, and isononyl isononanoate. Use cautiously.

Stability of 5% Ceracare™ Oil in different oil phases (1.5 months):

• Squalane: Turbid, little precipitation

• Isononyl isononanoate: Little precipitation

• MCT Oil: Excellent stability

• Wheat germ oil: Excellent stability

• Jojoba seed oil: Excellent stability

• Dimethicone: Turbidity and precipitation

Efficacy:

Ceramide NP - Efficacy Tests:

• Moisturization via aquaporin proteins

• Soothing (trypsin)

• Cell vitality (fibroblasts)

• Anti-wrinkle firming (elastase inhibition)

Ceramide NP - In Vitro Tests:

• Tested 0.2% ceramide barrier repair cream

• Subjects: 30 individuals (23-59 years old)

• Results: Significant reduction in skin redness, hemoglobin index, and trans-epidermal water loss (TEWL) after 4 weeks

Phytosphingosine - Efficacy:

• Soothing effect by down-regulation of IL-1α gene expression

• Effective oil control (5α-reductase inhibition)

• Antibacterial activity against Propionibacterium acnes

Ceramide AP & EOP:

• Ceramide AP has exfoliating efficacy

• Combined ceramide AP & EOP show positive effects on hydration and TEWL, particularly beneficial for damaged skin

Take-away Tips for Ceracare™ Oil:

• Mimics the ceramides complex ratio in human skin

• Suitable for transparent oil phases

• Stable with no precipitation

• Provides barrier repair, moisturizing, anti-allergy, and soothing effects

Use: The main ingredient in moisturizer products for sensitive skin, dry skin, aging skin, aging skin.

How to mix: Mix in oil phase of the formulation

Utilization rate: 0.1-3%

Product characteristics: transparent liquid

Solubility: Can be dissolved in many oils

Storage: Valid for 24 months, please store in the refrigerator at 6 °C -10 °C Premixed cosmetics should be stored in the refrigerator *Do not freeze, may cause ceramide to deteriorate*

INCI: Ceramide NP (CERAMIDE NP), Ceramide AP (CERAMIDE AP), Ceramide EOP (CERAMIDE EOP), Phytosphingosine (PHYTOSPHINGOSINE), Octyldodecanol (OCTYLDODECANOL), Pentylene Glycol (PENTYLENE GLYCOL)