HRC-4000™ (Human Type III Recombinant Collagen) is 4000ppm concentration of Human Type III Recombinant Collagen in liquid preparation.

Efficacy Testing Results (Tested at 10%, 2 times per day, 30 days):

1. Promotion of Anti-Wrinkle Gene Expression:

   • The expression of collagen-related genes increased by 88.46%.

2. Promotion of Collagen Synthesis and Inhibition of Collagen Degradation:

   • Collagen synthesis-related gene expression increased by 24%-38%.
   • Collagen degradation expression decreased by 8%-64%.

3. Collagen Enhancement:

   • Collagen fibers increased by 36.84%.
   • Type IV collagen increased by 35.21%.

4. Collagen Delivery:

   • The product reached the dermis within 4 hours.
   • It also reached the epidermis within 4 hours.

5. Photoaging Resistance:

   • RHC (Recombinant Human Collagen) significantly reduced photodamage and resisted photoaging.

6. Free Radical Scavenging:

   • RHC effectively increased fibroblast SOD activity, aiding in free radical scavenging.

7. Anti-Wrinkle and Smoothing Effects:

   • After 28 days, overall wrinkle size and depth reduced by 8.13%.
   • After 21 days, overall wrinkle size reduced by 9.11%, and depth by 9.82%.
   • After 35 days, wrinkle size reduced by 14.25%, and depth by 15.01%.

8. Skin Elasticity Improvement:

   • After 14 days, elasticity increased by 13.79%, and crow's feet reduced in number by 31.5% and length by 7.34%.
   • After 12 weeks, skin elasticity improved by 28.86%.
   • After 28 days, skin elasticity improved by 18.14%.

9. Gene Expression for Skin Barrier Enhancement:

   • LOR gene expression increased by 50.50% and TGM1 gene expression increased by 72.55%, improving the skin barrier.

10. Pore Volume Reduction:

    • After 28 days, pore volume improved by 48.46%.
    • After 42 days, pore volume improved by 57.94%.

11. Texture Roughness Improvement:

    • After 28 days, skin roughness improved by 16.40%.
    • After 35 days, skin roughness improved by 20.48%.

Other Research:

Citation: Ma, L., et al. (2015). "Topical Application of Recombinant Human Collagen Type III Promotes Wound Healing." Journal of Biomedical Materials Research Part A. DOI:10.1002/jbm.a.35478

Citation: Zheng, L., et al. (2016). "Recombinant Human Type III Collagen Hydrogels for Skin Hydration and Healing." Skin Pharmacology and Physiology. DOI:10.1159/000448646

Citation: Dai, Z., et al. (2017). "The Role of Human Recombinant Collagen in Reducing Wrinkles and Skin Aging." International Journal of Cosmetic Science. DOI:10.1111/ics.12455

Usage: Can be used in all skin care formulas for anti-aging.

Mixing method: Add in the last step, stir the base until it is completely dispersed in the formula. Avoid heat exceeding 40 degrees.

Usage rate: 1-20%

Product characteristics: clear to opaque liquid

Dissolving: soluble in water

Storage: Can be stored in a refrigerator (4 degrees), close the bottle tightly and keep away from sunlight or heat. The product has a shelf life of at least 2 years.

INCI Name : Water, Glycerin, 1,2-Hexanediol, Soluble Collagen

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