Hexylresorcinol AF is a water soluble version of 4-Hexylresorcinol, is an alkylresorcinol with many skin benefits:

• Whitening Care
• Age-spot treatment
• Photo-aging, brightening/lightening Care
• Underarm and bikini area spots
• Ethnic skin Care

Description:

Hexylresorcinol AF is a naturally effective cosmetic ingredient for the reduction of skin dark spots and skin whitening, without irritation effects. It has a significant reducing effect on tyrosinase activity and works synergistically on the three stages of the melanogenesis process:

1. Before melanin synthesis: Interferes in the synthesis and glycosylation of tyrosinase, preventing its absorption by the melanosome.
2. During melanin synthesis: Acts as a competitive inhibitor of tyrosinase, also affecting TRP1 and TRP2 enzymes, reducing melanogenesis-promoting byproducts.
3. After melanin synthesis: Enhances tyrosinase degradation, inhibits melanosome transfer to keratinocytes, and offers light peeling thanks to the fatty acids.

Benefits:

• Decreases melanin formation at the early stage of synthesis
• Reduces melanin synthesis and tyrosinase activity in skin melanocytes
• Reduces melanosome transfer to keratinocytes
• Promotes desquamation of superficial horny layers and melanin pigmentary residues
• Non-irritating effect

Clinical Efficacy Tests:

1. Whitening Effect:

Melanin synthesis inhibition vs Hydroquinone on melanocyte cell culture.

2. Tyrosinase Inhibition:

Spectrophotometric assay vs Kojic acid and Hydroquinone - 100% inhibition at 0.001%.

3. In-Vivo Whitening Efficacy:

20 volunteers, T=4 weeks - 94.6% inhibition (0.15 mg/L Hexylresorcinol AF).

Usage: Ingredients in any whitening formulation

Mixing method: Soluble in water

Usage rate: 1-3%

Product characteristics: Clear transparent light colored liquid

Solubility: Can dissolve in water

Storage: Shelf life: 24 months, stored at cold temperature. Avoid sunlight and heat.

INCI Name : Polysorbate 20, Hexylresorcinol, Caprylic Acid, Isopropyl alcohol, Peg-400, Caproic Acid, Capric Acid.