“Topical 5% tranexamic acid was studied for melasma/lightening benefit versus vehicle in a double-blind randomized prospective trial.”
Tranexamic Acid (Trans-White™)
Cosmetics
Code: 1140
Tranexamic acid works by whitening the skin and reducing the formation of melanin pigments, making it suitable for treating melasma.
This product can only be sold to buyers who have registered as cosmetic manufacturers. It cannot be purchased by the general public and cannot be used for anything other than cosmetic manufacturing.
Tranexamic acid brightens the skin and reduces the formation of melanin, making it suitable for treating melasma.
Tranexamic acid works most effectively when used to brighten skin, especially in cases of dark skin or melasma caused by sun exposure.
Widely used in products from Shiseido, Chanel, KOSE, Senka, ANESSA, and IPSA.
Add 0.5% ActiveProtec™ OX to the formulation to help prevent long-term discoloration.
Terms of Use:
Currently, the Thai FDA and FDA ASEAN permit the use of a maximum concentration of 3% in cosmetics for skin brightening purposes.
If the concentration exceeds 5%, it must be registered as a medication for treating melasma.
Do not use more than 5% as it may irritate the skin.
Do not use around the eyes or lips.
Uses: As a whitening agent to brighten skin and treat blemishes in creams, lotions, serums, or gels.
Mixing method: Mix in the water phase. It is directly water-soluble. The formula should have a pH in the range of 3-8.
Usage rate: 3% (If used at concentrations exceeding 3%, it must be registered as a medication for treating melasma. If used at concentrations not exceeding 3%, it can be registered as a cosmetic product.)
Product description: White powder.
Solubility: Soluble in water.
INCI Name : Tranexamic Acid
- Fridge (1-10C)
- Room (25-40C)
- 48 Months from manufacturing or testing date.
- 0.10% - 3.00%
- 3.00%
- Add into water phase. Avoid temperature above 60C.
- Avoid heat above 60C
- 3.00 - 8.00
- Soluble in Water
- Cream, Lotion, Clear Gel, Toner, Mask, Scrub
- -
| Test Name | Specification |
|---|---|
| Appearance | White or almost white crystal powder |
| Identification | IR |
| Solubility | Freely soluble in water and in glacial acetic acid, practically insoluble in acetone and in ethanol (96%) |
| pH | 7.0 - 8.0 |
| Loss on drying | <=0.5% |
| Residue on ignition | <=0.1% |
| Assay | 99.0% - 101.0% |
| Heavy Metal (As Pb) | <=10 ppm |
| As | <=2 ppm |
| Chloride | <=140 ppm |
| Related Substance : Impurity A | <=0.1% |
| Related Substance : Impurity B | <=0.2% |
| Related Substance : Total unspecified impurities | <=0.2% |
“Topical tranexamic acid used after IPL improved melasma outcomes as an adjuvant treatment in a randomized split-face study.”
“Topical 5% tranexamic acid showed comparable melasma improvement to 3% hydroquinone cream in Indian skin in a randomized controlled study.”
“Topical tranexamic acid was reported as an effective and safe option for melasma treatment in a clinical study; evidence scope is melasma, not general cosmetic brightening.”
“A systematic review/meta-analysis concluded tranexamic acid is effective and generally safe for melasma across oral, topical, and procedural delivery routes; topical evidence is included but mixed with other routes.”
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