4MSK (Potassium Methoxysalicylate)
Bleaching substances researched and developed by Shiseido are used in various products in the Whitening line of the Shiseido and IPSA brands.
4MSK (Potassium Methoxysalicylate), a Whitening substance with the Skin Bleaching process, was researched and developed by Shiseido. It is used in various products in the Whitening group of Shiseido and IPSA brands.
4MSK works by destroying melanocytes that remain beneath the surface of the skin.

Shiseido chooses to use 4MSK together with Tranexamic Acid and Vitamin C ( Ethyl Ascorbic Acid type) to perform Whitening duties together in the formula.

Usage: Used in whitening formulas to help brighten the skin.
Mixing method: Mix in water. Avoid heat above 60 degrees. *It is an electrolyte which may affect the texture of some gels/creams. Make the meat liquid
Usage rate: 1-3%, suitable for use with Tranexamic Acid.
Product appearance: light colored powder
Solubility: Can dissolve in water
INCI Name : Potassium Methoxysalicylate
Examples of products using Potassium Methoxysalicylate
SHISEIDO vital-perfection wrinklelift cream
SHISEIDO WHITE LUCENT Day Emulsion SPF 50+
SHISEIDO white lucent all day brightener spf36+++
SHISEIDO White Lucent All Day Brightener N 50ml
SHISEIDO White Lucent Day Emulsion Broad Spectrum SPF 23
SHISEIDO White Lucent Luminizing Surge 75ml
SHISEIDO White Lucent Microtargeting Spot Corrector 30ml
SHISEIDO Brightening gel cream
SHISEIDO White Lucent All Day Brightener Broad Spectrum SPF 22
SHISEIDO VITAL-PERFECTION Wrinklelift Mask
SHISEIDO VITAL-PERFECTION Wrinklelift Mask
SHISEIDO White lucent eye cream 2019
SHISEIDO White Lucent Brightening Gel Cream
SHISEIDO Future Solution LX Concentrated Balancing Softener
SHISEIDO White Lucent Overnight Cream & Mask
SHISEIDO White lucent overnight cream and mask
SHISEIDO Future Solution LX Total Radiance Foundation $92
IPSA Metabolizer Extra W
SHISEIDO OnMakeup Spot Correcting Serum SPF 25
SHISEIDO Future Solution LX Total Radiance Foundation
SHISEIDO vital perfection white circulator serum
- Room (25-40C)
- 36 Months from manufacturing or testing date.
- 0.10% - 3.00%
- 2.00%
- Add into water phase. Avoid temperature above 60C.
- Avoid heat above 60C
- 3.50 - 6.50
- Soluble in Water
- Cream, Lotion, Clear Gel, Toner, Mask, Scrub
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| Test Name | Specification |
|---|---|
| Appearance | Off-white powder |
| Identification (IR) | Consistent with reference product |
| Identification (HPLC) | Retention time of main peak same as control |
| Clarity of solution | Should be clear |
| Loss on drying (%) | ≤0.5 |
| pH (1% water solution) | 6.0-8.5 |
| Lead (Pb), ppm | ≤10 |
| Arsenic (As), ppm | ≤2 |
| Mercury (Hg), ppm | ≤1 |
| Cadmium (Cd), ppm | ≤5 |
| Total bacterial count (CFU/g) | ≤200 |
| Molds and yeast count (CFU/g) | ≤100 |
| Thermotolerant coliforms | Negative |
| Staphylococcus aureus | Negative |
| Pseudomonas aeruginosa | Negative |
| Purity (%) | ≥99.0 |