Ceramide EOP (90% Powder)

Ceramide EOP (90% Powder)
Cosmetics Code: 127708

Ceramide EOP (Pure 90% Powder)

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Ceramide EOP (Pure 90% Powder)

# Benefit Supporting Findings
1 Accelerates barrier repair – Fills lamellar gaps between corneocytes and restores the long periodicity lamellar phase. Human ex-vivo barrier disruption models demonstrated a 25–30% faster recovery of electrical impedance when Ceramide EOP was applied in a 3:1:1 molar blend with cholesterol and free fatty acids. (J Clin Invest, 1993; Elias et al.)
2 Reduces transepidermal water loss (TEWL) and improves hydration Two 4-week split-face studies reported reductions in TEWL by 15–40% and increases in corneometer hydration by 12–25% compared to vehicle. (Acta Derm Venereol, 2003; Loden et al.)
3 Improves dry skin and atopic dermatitis symptoms Randomized clinical trials in both adults and children with mild-to-moderate atopic dermatitis showed reductions in SCORAD scores by 35–50%, reductions in itch (visual analog scale) by 40%, and significant improvement in erythema (measured using Lab* color metrics) after regular application of Ceramide EOP-containing moisturizers. (Pediatr Dermatol, 2008; Chamlin et al.)
4 Replenishes deficient ω-hydroxy ceramides in aged or diseased skin Lipidomic analysis revealed restoration of long-chain ω-hydroxy ceramides (C30–C34) and improved organization of the long periodicity lamellar phase after two weeks of treatment. (J Lipid Res, 2002; Uchida et al.)
5 Improves skin texture and reduces visible scaling Measurements using Visioscan® and D-Squames® techniques showed reductions in scaliness and surface roughness by 20–30%, and normalization of corneocyte exfoliation. (Skin Res Technol, 2011; Voegeli et al.)
6 Enhances anti-inflammatory effects when combined with actives like glycerol and niacinamide Studies with reconstructed epidermis showed that combinations of Ceramide EOP with glycerol, niacinamide, or phytosphingosine significantly accelerated barrier recovery and decreased IL-4 and TSLP cytokine expression. (Exp Dermatol, 2010; Kim et al.)




Formulation Guidelines:

  • Use at 0.1–0.5% Ceramide EOP active. Combine with cholesterol and long-chain fatty acids (C16–C24) at a physiologic 3:1:1 molar ratio.

  • Best delivered in lamellar emulsions using emulsifiers like glyceryl stearate, cetearyl alcohol, or lecithin.

  • Stable in formulations with pH between 4.5–7. Avoid anionic surfactants and high-ethanol systems which can disrupt lipid structures.

  • Combine with occlusives and humectants (like petrolatum or glycerin) for synergistic hydration and barrier enhancement.

 



Use: The main ingredient in moisturizer products for sensitive skin, dry skin, aging skin, aging skin.

How to mix: Mix in the oil portion of the formula. Can withstand heat up to 90 degrees, dissolves well in oil at temperatures from 75 degrees or more.

Utilization rate: 0.01-0.2% (0.1% recommended)

Product characteristics: White-light yellow powder

Solubility: It can dissolve in oil and some fatty alcohols.

Storage: please store in the refrigerator at 6 °C -8 °C Mixed cosmetics should be stored in the refrigerator.

 

INCI Name : Ceramide EOP


  • Room (25-40C)
  • 36 Months from manufacturing or testing date.
  • 0.01% - 0.20%
  • 0.10%
  • Add into oil phase. Heat tolerant.
  • Avoid heat above 90C
  • 3.50 - 6.50
  • Soluble in Oil, Dispersible in cream or gel base, Dispersible in powder
  • Cream, Lotion, Serum
  • -
Test Name Specification
Appearance White or off-white particles
Identification The retention time of the main peak of the test solution was the same as that of the main peak of the control solution. The retention time of the main peak of the test solution is consistent with that of the main peak of the reference solution.
Water NMT 2.0%
Residue on ignition NMT 0.5%
Heavy metals NMT 20ppm
Purity NLT 90.0%
Total aerobic bacteria NMT 1000CFU/g
Yeast & Mold NMT 100CFU/g

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Ceramide EOP (90% Powder)

Ceramide EOP (Pure 90% Powder)

Ceramide EOP (Pure 90% Powder)

# Benefit Supporting Findings
1 Accelerates barrier repair – Fills lamellar gaps between corneocytes and restores the long periodicity lamellar phase. Human ex-vivo barrier disruption models demonstrated a 25–30% faster recovery of electrical impedance when Ceramide EOP was applied in a 3:1:1 molar blend with cholesterol and free fatty acids. (J Clin Invest, 1993; Elias et al.)
2 Reduces transepidermal water loss (TEWL) and improves hydration Two 4-week split-face studies reported reductions in TEWL by 15–40% and increases in corneometer hydration by 12–25% compared to vehicle. (Acta Derm Venereol, 2003; Loden et al.)
3 Improves dry skin and atopic dermatitis symptoms Randomized clinical trials in both adults and children with mild-to-moderate atopic dermatitis showed reductions in SCORAD scores by 35–50%, reductions in itch (visual analog scale) by 40%, and significant improvement in erythema (measured using Lab* color metrics) after regular application of Ceramide EOP-containing moisturizers. (Pediatr Dermatol, 2008; Chamlin et al.)
4 Replenishes deficient ω-hydroxy ceramides in aged or diseased skin Lipidomic analysis revealed restoration of long-chain ω-hydroxy ceramides (C30–C34) and improved organization of the long periodicity lamellar phase after two weeks of treatment. (J Lipid Res, 2002; Uchida et al.)
5 Improves skin texture and reduces visible scaling Measurements using Visioscan® and D-Squames® techniques showed reductions in scaliness and surface roughness by 20–30%, and normalization of corneocyte exfoliation. (Skin Res Technol, 2011; Voegeli et al.)
6 Enhances anti-inflammatory effects when combined with actives like glycerol and niacinamide Studies with reconstructed epidermis showed that combinations of Ceramide EOP with glycerol, niacinamide, or phytosphingosine significantly accelerated barrier recovery and decreased IL-4 and TSLP cytokine expression. (Exp Dermatol, 2010; Kim et al.)




Formulation Guidelines:

 



Use: The main ingredient in moisturizer products for sensitive skin, dry skin, aging skin, aging skin.

How to mix: Mix in the oil portion of the formula. Can withstand heat up to 90 degrees, dissolves well in oil at temperatures from 75 degrees or more.

Utilization rate: 0.01-0.2% (0.1% recommended)

Product characteristics: White-light yellow powder

Solubility: It can dissolve in oil and some fatty alcohols.

Storage: please store in the refrigerator at 6 °C -8 °C Mixed cosmetics should be stored in the refrigerator.

 

INCI Name : Ceramide EOP

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