Ceramide 3 (Ceramide NP, N-oleoyl-phytosphingosine type) - High purity powder ceramide (>90%) equivalent to Croda Y3O or Evonik IIIB. Essential for barrier repair.

Ceramide 3 (also known as Ceramide NP, N-oleoyl-phytosphingosine type)™ is a high-purity powder form ceramide with over 90% purity, structurally similar to ceramides found naturally in human skin.

This specific variant contains N-oleoyl-phytosphingosine as the primary fatty acid chain, equivalent to commercial products like Croda Y3O or Evonik IIIB. Ceramide NP is one of the most important ceramides for maintaining skin barrier function, helping to lock in moisture and protect against environmental stressors.

N-oleoyl-phytosphingosine variant provides enhanced compatibility with skin lipids due to its oleic acid chain, offering superior moisturization and barrier repair properties. It works by replenishing the skin's natural ceramide levels, which decline with age and environmental damage.

Clinical Research & Evidence:

Reinforce the skin barrier & cut water loss. Randomized and controlled clinical trials of ceramide-containing moisturizers show significant improvements in transepidermal water loss (TEWL) and hydration versus comparators, with parallel improvements in eczema severity scores. Most formulas in these studies include Ceramide NP among other skin-identical lipids.

Improve signs/symptoms of eczema & dermatitis. In adults with eczema, a ceramide-dominant regimen improved barrier function and symptoms; a separate RCT in mild–moderate atopic dermatitis found a ceramide cream (vs. hydrocortisone or standard emollient) improved hydration and clinical scores.

Direct relevance of NP subclass to barrier quality. Observational work links a higher Ceramide NP : NS ratio in the stratum corneum with healthier barrier properties; modeling data also show that changing the NS:NP ratio alters lipid packing and permeability—supporting NP's structural role in barrier integrity.

Mechanistic fit: fills lipid "mortar." Reviews of phytosphingosine-based ceramides (including CER[NP]) describe how they assemble with cholesterol and free fatty acids into lamellar structures that maintain cohesion, resilience, and water retention in the outer skin layer.

Usage: Suitable for all skincare products including creams, lotions, serums, anti-aging formulations, and barrier repair treatments. Ideal for dry and sensitive skin products.

How to mix:

- Pre-disperse in oil phase at 70-80°C until fully dissolved

- Can be combined with other ceramides and cholesterol for enhanced barrier repair

- Add to formulation during oil phase incorporation

Usage rate: 0.1-2.0%

Product Description: White to light yellow powder with purity greater than 90%

Solubility: Soluble in oils and organic solvents at elevated temperature (70-80°C), insoluble in water

Storage: Store in a cool, dry place away from light. Keep container tightly closed. Shelf life 2 years.

INCI Name: Ceramide NP