“Closest topical nano-HA clinical evidence: nano-hyaluronic acid improved wrinkle depth, hydration, firmness, and elasticity after 8 weeks; exact 800 Da material was not specified.”
Hyaluronic Acid (Nano Molecule, 800daltons)
Cosmetics
Code: 35933
Nano 800 Da Hydrolyzed Hyaluronic Acid powder for very light water-based hydration and anti-aging focused formulas.
Hyaluronic Acid (Nano Molecule, 800daltons) is a cosmetic hyaluronic acid powder for water-based moisturising formulas.
This grade is Hydrolyzed Hyaluronic Acid with molecular weight 800-1,000 Da. It is designed for very low molecular weight hydration and anti-aging focused water-phase formulas.
Molecular weight strongly changes how hyaluronic acid behaves in a formula: lower molecular weight grades give a lighter skin feel, while higher molecular weight grades contribute more surface hydration, viscosity and film feel.
Product Description: This nano-molecule grade is selected when the formula needs a very light, low-viscosity hyaluronic acid profile. The very low molecular weight supports fast hydration feel and anti-aging hydration concepts without the gel build expected from larger polymers.
The grade is specified as white to almost white powder with molecular weight around 800 Da. It is suitable where formula color clarity is important.
Low molecular weight hyaluronic acid is more ionic than high molecular weight grades and can reduce viscosity in some polymer-thickened systems. Use electrolyte-resistant thickeners when building gels or transparent serums.
When the formula is not already preserved, add an appropriate preservative system. Hydrated hyaluronic acid gels are water-rich systems and can lose viscosity or become contaminated without preservation.
Usage: Suitable for hydrating serums, gels, lotions, creams, masks, essences and other water-phase cosmetic products.
Mixing method:
- Disperse slowly into the water phase while mixing. Sprinkle onto the water surface gradually to avoid clumps.
- For small lab batches without a homogenizer, shake or mix well, then allow time for full hydration before final viscosity adjustment.
- Maintain final formula pH about 3-9 and avoid unnecessary high heat or excessive shear after hydration.
Usage rate: 0.1-0.5%
Product characteristics: White to light-colored powder, non-yellow grade, molecular weight about 800 Da.
Solubility: Water soluble. Hydration is easier when the powder is added slowly into a moving water phase.
Storage: Keep tightly closed in a cool, dry place away from sunlight and heat. For long-term storage, refrigeration is acceptable when condensation is avoided.
INCI Name: Hydrolyzed Hyaluronic Acid
- Room (25-40C)
- 24 Months from manufacturing or testing date.
- 0.10% - 0.50%
- 0.10%
- Add into water phase. Avoid temperature above 60C.
- Avoid heat above 60C
- 3.00 - 9.00
- Soluble in Water
- Cream, Lotion, Serum
- -
| Test Name | Specification |
|---|---|
| Character | White or almost white powder or granules |
| Identification - Infrared absorption | Consistent with the reference spectrum of sodium hyaluronate |
| Identification - Reaction of sodium | Positive |
| Loss on drying | ≤10.0% |
| Molecular weight | 800Da |
| Limiting viscosity | 0.07dL/g |
| pH | 5.0～8.5 |
| Transparency | ≥99.0% |
| Protein | ≤0.1% |
| Heavy metals (as Pb) | <20mg/kg |
| Microbial limit - Bacteria counts | ≤100cfu/g |
| Microbial limit - Molds & Yeasts | ≤50cfu/g |
| Staphylococcus aureus | Negative |
| Pseudomonas aeruginosa | Negative |
| Glucuronic acid (on dried basis) | ≥44.5% |
| Sodium hyaluronate (on dried basis) | ≥92.0% |
“Topical 0.1% HA creams across 50–2000 kDa improved skin hydration and elasticity; 50 and 130 kDa showed significant wrinkle-depth improvement, but this is higher MW than 800 Da.”
“Mechanistic support for low-MW HA: 50 kDa HA showed better skin penetration and upregulated epidermal barrier/differentiation-related genes without increasing TNF-alpha; not exact 800 Da.”
“A topical HA serum improved facial hydration, plumpness, fine lines/wrinkles, and global photoaging appearance in a clinical study; HA molecular weight was not specific to 800 Da.”
“Recent randomized trial in elderly xerosis found low-MW HA moisturizer improved skin capacitance more than high-MW HA and vehicle; direct evidence supports low-MW HA hydration, not exact 800 Da anti-wrinkle claims.”
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