“Topical 0.1% hyaluronic acid formulations improved skin hydration and elasticity; lower-MW HA showed stronger wrinkle-depth effects than higher-MW forms, so this is ingredient-family evidence, not exact 2 MDa proof.”
Hyaluronic Acid (Large Molecule, 2M Daltons)
Cosmetics
Code: 1351
Large-molecule 2M Da Sodium Hyaluronate powder for stronger surface hydration, gel body and a more noticeable moisture film.
Hyaluronic Acid (Large Molecule, 2M Daltons) is a cosmetic hyaluronic acid powder for water-based moisturising formulas.
This grade is Sodium Hyaluronate with molecular weight 1.8M-3.0M Da. It is designed for strong surface hydration, gel body and a more noticeable moisture film.
Molecular weight strongly changes how hyaluronic acid behaves in a formula: lower molecular weight grades give a lighter skin feel, while higher molecular weight grades contribute more surface hydration, viscosity and film feel.
Product Description: This large-molecule grade remains mainly on the skin surface. It is selected when the formula needs more cushion, more gel body, stronger surface water binding and a more perceptible film than standard-molecule hyaluronic acid.
COA specification includes sodium hyaluronate minimum 95%, glucuronic acid minimum 46%, pH 6.0-7.5 in 0.1% water solution and molecular weight 1.8M-3.0M Da.
When the formula is not already preserved, add an appropriate preservative system. Hydrated hyaluronic acid gels are water-rich systems and can lose viscosity or become contaminated without preservation.
Usage: Suitable for hydrating serums, gels, lotions, creams, masks, essences and other water-phase cosmetic products.
Mixing method:
- Disperse slowly into the water phase while mixing. Sprinkle onto the water surface gradually to avoid clumps.
- For small lab batches without a homogenizer, shake or mix well, then allow time for full hydration before final viscosity adjustment.
- Maintain final formula pH about 3-9 and avoid unnecessary high heat or excessive shear after hydration.
Usage rate: 0.1-0.5%
Product characteristics: White powder, average molecular weight about 2M Da, specification range 1.8M-3.0M Da.
Solubility: Water soluble. Hydration is easier when the powder is added slowly into a moving water phase.
Storage: Keep tightly closed in a cool, dry place away from sunlight and heat. For long-term storage, refrigeration is acceptable when condensation is avoided.
INCI Name: Sodium Hyaluronate
- Fridge (1-10C)
- Room (25-40C)
- 24 Months from manufacturing or testing date.
- 0.10% - 0.50%
- 0.10%
- Add into water phase. Avoid temperature above 60C.
- Avoid heat above 60C
- 3.00 - 9.00
- Soluble in Water
- Cream, Lotion, Clear Gel, Toner, Mask
- -
| Test Name | Specification |
|---|---|
| Appearance | White powder or granule |
| Odor | Odorless |
| Glucuronic acid content | Min 46.0% |
| Sodium hyaluronate content | Min 95.0% |
| Molecular weight | 1.8M~3.0MDa |
| pH (0.1% water solution) | 6.0~7.5 |
| Protein | Max 0.05% |
| Limiting viscosity | 27.3-40.6 dl/g |
| Transparency (0.1% water solution) | Min 99.0% |
| Residue on ignition | Max 20.0% |
| Loss on drying | Max 10.0% |
| Heavy metals (as Pb) | Max 20 ppm |
| Arsenic | Max 2 ppm |
| Hemolysis | Negative |
| Total plate count | Max 100 CFU/g |
| Total yeast and mold | Max 50 CFU/g |
| Pseudomonas aeruginosa | Negative |
| Staphylococcus aureus | Negative |
| Viable hemolytic streptococcus | Negative |
“High-molecular-weight HA mainly supports surface hydration/film-forming and water retention; this supports the product’s large-molecule moisturizing/coating positioning.”
“Review of topical HA cosmeceuticals reports evidence for improved skin hydration, rejuvenation, firmness, elasticity, and wrinkle appearance; closest ingredient-family evidence.”
“A topical HA-containing serum improved skin plumpness, hydration, smoothness, and fine-line appearance in clinical evaluation; formulation evidence rather than exact 2 MDa HA alone.”
“A randomized trial in elderly xerosis found topical HA improved dry skin, with molecular weight influencing hydration performance; supports HA use for xerosis but not exact commercial 2 MDa material.”
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