“Closest low-molecular-weight HA evidence: topical 0.1% HA creams at 50 and 130 kDa significantly reduced periocular wrinkle depth; all tested HA molecular weights improved skin hydration and elasticity versus placebo.”
Hyaluronic Acid (Small Molecule, 8-20K Daltons)
Cosmetics
Code: 105
Small-molecule 8-20K Da Hydrolyzed Hyaluronic Acid powder for lightweight water-based hydration with low viscosity contribution.
Hyaluronic Acid (Small Molecule, 8-20K Daltons) is a cosmetic hyaluronic acid powder for water-based moisturising formulas.
This grade is Hydrolyzed Hyaluronic Acid with molecular weight 8,000-20,000 Da. It is designed for lightweight hydration with low viscosity contribution.
Molecular weight strongly changes how hyaluronic acid behaves in a formula: lower molecular weight grades give a lighter skin feel, while higher molecular weight grades contribute more surface hydration, viscosity and film feel.
Product Description: This small-molecule grade is useful when a formulator wants a lighter feel and less gel build than standard or large-molecule sodium hyaluronate. It is suitable for watery serums, essences, toners and low-viscosity hydrating systems.
COA specification includes sodium hyaluronate minimum 95%, glucuronic acid minimum 46%, pH 6.0-7.5 in 0.1% water solution and molecular weight 8,000-20,000 Da.
When the formula is not already preserved, add an appropriate preservative system. Hydrated hyaluronic acid gels are water-rich systems and can lose viscosity or become contaminated without preservation.
Usage: Suitable for hydrating serums, gels, lotions, creams, masks, essences and other water-phase cosmetic products.
Mixing method:
- Disperse slowly into the water phase while mixing. Sprinkle onto the water surface gradually to avoid clumps.
- For small lab batches without a homogenizer, shake or mix well, then allow time for full hydration before final viscosity adjustment.
- Maintain final formula pH about 3-9 and avoid unnecessary high heat or excessive shear after hydration.
Usage rate: 0.1-0.5%
Product characteristics: White powder, molecular weight 8,000-20,000 Da.
Solubility: Water soluble. Hydration is easier when the powder is added slowly into a moving water phase.
Storage: Keep tightly closed in a cool, dry place away from sunlight and heat. For long-term storage, refrigeration is acceptable when condensation is avoided.
INCI Name: Hydrolyzed Hyaluronic Acid
- Fridge (1-10C)
- Room (25-40C)
- 24 Months from manufacturing or testing date.
- 0.10% - 0.50%
- 0.10%
- Disperse slowly into water vortex. Allow 30+ minutes hydration time. Avoid temperature above 50C and excessive shear.
- Avoid heat above 60C
- 3.00 - 9.00
- Soluble in Water, Soluble in glycols, Soluble in Ethanol
- Cream, Lotion, Clear Gel, Toner, Mask, Cleanser, Lip, Foundation, Primer, Concealer, Mascara, Eye Liner, Sun Screen
- -
| Test Name | Specification |
|---|---|
| Appearance | Fine white or White powder |
| Odor | Odorless |
| Glucuronic Acid | Min 46.0% |
| Sodium Hyaluronate | Min 95.0% |
| Molecular Weight | 8,000-20,000Da |
| pH (0.1% Water Solution) | 6.0 ~ 7.5 |
| Protein | Max 0.05% |
| Limiting viscosity | 0.28~0.81dl/g |
| Transparency (0.1% Water Solution) | Min 99.0% |
| Residue on ignition | Max 20.0% |
| Loss on drying | Max 10.0% |
| Heavy Metals (as Pb) | Max 20ppm |
| Arsenic | Max 2ppm |
| Hemolysis | Negative |
| Total plate count | Max 100 CFU/g |
| Total yeast & mold | Max 50 CFU/g |
| Pseudomonas aeruginosa | Negative |
| Staphylococcus aureus | Negative |
| Viable hemolytic streptococcus | Negative |
“Closest nano/low-MW HA evidence: topical nano-hyaluronic acid serum significantly improved wrinkle depth and skin hydration in human facial skin.”
“Topical HA ingredient-family evidence: a facial serum containing HA improved skin hydration, plumpness, fine lines, wrinkles, and overall photoaged skin appearance in a clinical study.”
“Ingredient-family review evidence: HA is a key skin extracellular-matrix molecule involved in skin moisture, viscoelasticity, aging, and tissue repair; topical benefits depend partly on molecular weight and formulation.”
“Authoritative topical HA review evidence: clinical studies support topical HA for improving skin hydration, elasticity, and visible signs of aging, with low-MW HA formulations showing particular relevance for wrinkle improvement.”
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