Franz diffusion cell (เส้นผ่านศูนย์กลาง 20 มม.) หัวฉีดคู่

The Franz diffusion cell is a laboratory apparatus used in pharmaceutical and dermatological research to assess the permeability and diffusion of substances through biological membranes, particularly the skin. It is named after its inventor, Max Franz. This device helps researchers study how drugs, creams, lotions, and other substances interact with and penetrate the skin.

The Franz diffusion cell consists of two compartments separated by a biological membrane or a piece of tissue, typically human or animal skin. Here's how it works:

Donor Compartment: This is the upper compartment of the cell, and it contains the substance (e.g., a drug formulation or topical cream) to be tested. The substance is applied to the surface of the skin or membrane.

Receiver Compartment: This is the lower compartment, which holds a receptor solution. The receptor solution is designed to mimic the physiological conditions of the skin or the specific tissue under study. It is used to collect and measure the amount of the substance that has diffused through the membrane.

Membrane: The biological membrane (e.g., skin) is clamped between the donor and receiver compartments. The membrane acts as a barrier that the substance must penetrate to reach the receptor solution. The properties of the membrane, such as its thickness and composition, can vary depending on the research objectives.

Sampling: Over time, the substance in the donor compartment diffuses through the membrane and into the receptor solution. Researchers can periodically sample the receptor solution to measure the concentration of the substance. This allows them to calculate the rate and extent of permeation or diffusion through the membrane.

The Franz diffusion cell is essential for assessing the effectiveness of topical medications, cosmetic products, and transdermal drug delivery systems. By using this device, researchers can determine factors such as the permeability coefficient, diffusion rate, and release kinetics of substances across biological membranes. This information is crucial for the development and optimization of drugs and skincare products, as it helps ensure that they effectively penetrate the skin and reach their target site.